I
was working in an infectious disease medicine group at a major academic
hospital. The holidays were fast coming
upon us, so the hospital was all decked out with merry decorations of green and
red. As I came into work that day I was
still feeling stuffed from all that I had eaten the day before on Thanksgiving.
Usually
such a holiday weekend, though being a long with needing to work 3 days, would
be quiet. We didn’t get a lot of
admissions, and most patients were asking to be discharged, instead being
followed as out-patients.
It
was into this picture, that I received a page from my supervising physician to
go down to the emergency room and see a 35 year old male patient. From the sounds of it, he was ill and needed
to be admitted to the hospital. I
scurried down to the emergency room and began working the new patient up.
Upon
arriving in the emergency room, I walked over to the curtain and pulled it
aside. Laying in the bed was a
middle-aged man, with his eyes closed trying not to move.
“Hi,
I’m Sharon, I’m a physician assistant and was asked to come down and see
you. Am I to assume you’re Tom Arnold?”
“Um,
yeah, I’m Tom.”
“I’ve
been told you have a really bad headache and a fever. What can you tell me about your symptoms?”
“Um,
can you pull that curtain behind you, so that it’s closed? The light is really bothering my eyes.”
“Sure,”
and with that I pulled it closed again, trying to block as much light as I
could from the emergency room overhead lights.
“Thanks.”
“Okay,
can you tell me when you started getting sick?”
“Yesterday,
I woke up not feeling very well, but with it being Thanksgiving and all I had
to get up and help my wife keep an eye on our three kids. So with my keeping an eye on the kids, my
wife stayed in the kitchen fixing our holiday meal. As yesterday wore on, I started feeling
worse, my head really started hurting and I started feeling somewhat
nauseated. By dinner, I just didn’t want to eat, I was afraid that
I would just throw it back up. So I sat
at the dinner table and just sipped some cold water. After dinner, I couldn’t stay awake any
longer, I felt so bad I went back to bed.”
“So,
when did you fevers start?”
“Probably
some time in the afternoon, yesterday.”
“Do
you have any other symptoms?”
“Yeah,
now that you ask, my neck really hurts. I
also have a runny nose, it’s like a water faucet, just clear drainage.”
“Any
rash, or other symptoms?”
“No.”
“Anyone
in your family ill, lately?”
“Yeah,
my three year old son just got over a really bad cold, he’d had it for over a
week, before he finally cleared the cold virus.
I spent quite a few nights rocking him to sleep because he was having a
hard time sleeping due to his cough and nasal congestion.”
“Okay,
well I have a few more questions for you.
Do you have any chronic medical conditions, such as hypertension, or
diabetes?”
“No.”
“So,
you’re not on any daily medications?”
“No,
I don’t take anything.”
I
asked him about his family history, social history and found out that it was
all non-contributory. He worked as an
electrical engineer for the local gas company.
“We’re
going to have to do a lumbar puncture on you to see whether you have
meningitis. I’ll also have the nurse
come in and draw blood cultures, a blood count and blood chemistry panel on
you. I’ll be back with the infectious
disease fellow who will do the lumbar puncture. I see that they have already started an IV
on you and begun to run some fluids into you, which should help to bring down
your fever of 102 F. I’ll also have the
nurse give you some Tylenol for your headache/fevers. We’ll get the testing done as soon as
possible. Any questions?”
“No,
I don’t think so. What do you think I
have?”
“It
sounds as though you have meningitis, it could be viral meningitis, seeing that
your son has had a cold.”
“Oh,
that sounds bad.”
“No,
not necessarily. Let us finish our
testing first. Let me go get the nurse
assigned to you to draw your blood work and I’ll come back and do my exam,
listening to your lungs, heart, etc.
After that I’ll page the the infectious disease fellow to come down and
do your lumbar puncture.”
“Um,
okay, as long as I can get that Tylenol pretty quickly, my head is just
throbbing.”
“I’ll
be back shortly.”
A
half-hour later, I had completed the patient’s physical exam and the nurse had
gotten all of his blood work drawn. Besides
his stiff neck and runny nose I didn’t find anything else on his physical
exam. I called my infectious disease
fellow and he showed up within a few minutes to do the lumbar puncture. After drawing off several tubes of spinal
fluid, the ID fellow left and I completed writing out the admission
orders. Now it was time for the lab to
tell us what the cell count was and we would know shortly what kind of
meninigitis we were dealing with.
Patients who present
with meningitis generally have acquired it from one of several risk
factors.
Viral meningitis: which is typically caused by herpes, HIV,
mumps, varicella (chicken pox), or enterovirus (typical common cold virus for
instance).
Tuberculosis,
Fungus (in
immunocompromised patients who are on chemotherapy for cancer, for instance),
Tick borne from lyme
disease or rocky mountain spotted fever,
Syphilis,
Bacterial related, such
as from strep bacteria, gonorrhea strains, H. flu
Neoplasm spread:
usually from leukemia
Drug induced: several
different drugs can induce a meningitis type picture
The usual signs and
symptoms of meningitis include: light sensitivity (photosensitivity), nausea,
vomiting, fatigue, malaise, neck rigidity, headache, fever, abrupt onset of
symptoms as well as a possible rash.
Patients typically look ill, they don’t want to move around and they
prefer a dark room.
I
went back upstairs and joined my team on afternoon rounds, which had just
started. Twenty minutes later the ID fellow was paged and came back to tell me
that our new patient we had seen in the emergency room looked to have viral
meningitis, based on his spinal tap results.
The nurses were getting him situated on 21East, a medicine floor. That was our next floor down, so the team
would be seeing him shortly.
The
patient’s cell count from his lumbar puncture showed him to have a white blood
cell count of 150, a normal glucose, a normal protein count. His blood work showed that he had a blood
white blood cell count that was predominately lymphocytes (which fight off
virus’), a normal chem 7 (electrolytes and renal function). With the history of his son having a recent
viral infection, he did indeed have
a case of viral meningitis. So now he
just needed to be kept hydrated, get plenty of Tylenol for his headaches, give
him some Ativan for his nausea/vomiting and see how he was in the am. If he, as other patients with viral
meningitis have done, felt better then we could discharge him home and have him
see his primary care physician in a week to make sure all of his symptoms had
resolved.
Doing a lumbar
puncture (spinal tap) is the most important test to do on patients who are
suspected of having meningitis. The
various tests that we can run on the spinal fluid tells us a lot. The cell count will tell us whether we are
dealing with a viral infection (the count will come back with a predominance of
lymphocytes), bacterial infection (cell count will be a predominance of
neutrophils), or some other etiology, such as neoplastic spread (immature cells
called blasts will be present). Gram
staining will be positive if it is a bacterial infection. In bacterial meningitis there is also usually
a high protein and low glucose count.
(bacteria produce protein, use glucose).
Blood counts for the
patient’s white blood cell count, differential of those white blood cells, as
well as the patient’s electrolytes and renal function (kidneys) is important to
know. Electrolytes and renal function
will tell you how hydrated the patient is (i.e. how much nausea/vomiting
they’ve had).
Patients who have a
bacterial origin for their meningitis need to be started on IV antibiotics
immediately after their spinal tap. The
type of IV antibiotics is based upon the patient’s age, immune status, and
possibly risk factors. They also need to
receive IV hydration to help keep their fever down as well as help prevent any
pre-renal azotemia (dehydration that leads to increased renal parameters, i.e.
renal insufficiency.)
The
following morning before rounds I went to go check on my newly admitted
patient. He was sleeping comfortably,
with his wife sitting in the chair besides him.
I quietly asked her whether he had been able to eat anything and she
said he had a snack last night and keep it down. The nurse’s notes stated that his fevers had
stayed down with him being on Tylenol. I
excused myself and went out to the nurse’s station and began writing his
discharge orders. This father would do
fine. He had learned yet another lesson
in parenting, how kids love passing on their bugs to anyone around them,
especially their mom and dad.
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